Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation.

ABSTRACT: The prevalence of chronic kidney disease (CKD) is rising worldwide and 10-15% of the global population currently suffers from CKD and its complications. Given the increasing prevalence of CKD there is an urgent need to find novel treatment options. The American black bear (Ursus americanus) copes with months of lowered kidney function and metabolism during hibernation without the devastating effects on metabolism and other consequences observed in humans. In a biomimetic approach to better understand kidney adaptations and physiology in hibernating black bears, we established a high-quality genome assembly. Subsequent RNA-Seq analysis of kidneys comparing gene expression profiles in black bears entering (late fall) and emerging (early spring) from hibernation identified 169 protein-coding

SUBMITTER: Srivastava A 

PROVIDER: S-EPMC6379037 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature