A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.

ABSTRACT: Genome-, transcriptome- and proteome-wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are expressed and in which quantities are not fully understood. Therefore, we generated a quantitative proteome and transcriptome abundance atlas of 29 paired healthy human tissues from the Human Protein Atlas project representing human genes by 18,072 transcripts and 13,640 proteins including 37 without prior protein-level evidence. The analysis revealed that hundreds of proteins, particularly in testis, could not be detected even for highly expressed mRNAs, that few proteins show tissue-specific expression, that strong differences between mRNA and protein quantities within and across tissues exis

SUBMITTER: Wang D 

PROVIDER: S-EPMC6379049 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature