Assessment of Tumor Redox Status through (S)-4-(3-[¹⁸F]fluoropropyl)-L-Glutamic Acid PET Imaging of System x_c ^- Activity.

ABSTRACT: The cell's endogenous antioxidant system is vital to maintenance of redox homeostasis. Despite its central role in normal and pathophysiology, no noninvasive tools exist to measure this system in patients. The cystine/glutamate antiporter system x_c ^- maintains the balance between intracellular reactive oxygen species and antioxidant production through the provision of cystine, a key precursor in glutathione biosynthesis. Here, we show that tumor cell retention of a system x_c ^--specific PET radiotracer, (S)-4-(3-[¹⁸F]fluoropropyl)-L-glutamic acid ([¹⁸F]FSPG), decreases in proportion to levels of oxidative stress following treatment with a range of redox-active compounds. The decrease in [¹⁸F]FSPG retention c

SUBMITTER: McCormick PN 

PROVIDER: S-EPMC6379064 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature