Protective effect of myricetin derivatives from Syzygium malaccense against hydrogen peroxide-induced stress in ARPE-19 cells.

ABSTRACT:

Purpose

Oxidative stress is implicated in the etiology of diabetes and its debilitating complications, such as diabetic retinopathy (DR). Various flavonoids have been reported to be useful in reducing DR progression. Myricetin derivatives (F2) isolated from leaf extract of Syzygium malaccense have the potential to serve as functional food as reported previously. The present study was performed with the aim of determining the antioxidant potential and protective effect of myricetin derivatives (F2) isolated from leaf extract of S. malaccense against glucose oxidase (GO)-induced hydrogen peroxide (H₂O₂) production that causes oxidative stress in ARPE-19 (RPE) cells.

Methods

Antioxidant properties were assessed through various radical (DPPH,

SUBMITTER: Arumugam B 

PROVIDER: S-EPMC6379087 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature