Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes.

ABSTRACT: The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53^+/-) mice has not been investigated. We hypothesized that p53^+/- mice would be susceptible to lung tumor development after exposure to either tangled (t-) or rod-like (r-) MWCNTs. Wild-type (p53^+/+) or p53^+/- mice were exposed to MWCNTs (1 mg/kg) via oropharyngeal aspiration weekly over four consecutive weeks and evaluated for cellular and pathologic outcomes 11-months post-initial e

SUBMITTER: Duke KS 

PROVIDER: S-EPMC6379105 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature