Programmed Degradation of Hydrogels with a Double-Locked Domain.

ABSTRACT: The ability to control the degradation of a material is critical to various applications. The purpose of this study was to demonstrate a concept of controlling degradation by using a double-locked domain (DLD). DLDs are molecular structures with two functional units that work cooperatively under environmental stimulation. One unit is triggered to transform without cleavage in the presence of the first stimulus, but this transformation enables the activation of the other unit for cleavage in the presence of the second stimulus. A DLD is presented that is activated to transform through intramolecular reconfiguration when exposed to light. After this transformation, the light-triggered DLD can undergo rapid cleavage under acid treatment. When this DLD is used as the crosslinkers of hydrogels,

SUBMITTER: Lai J 

PROVIDER: S-EPMC6379111 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature