Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers.

ABSTRACT:

Aims

The anthelminthic ivermectin is receiving new attention as it is being repurposed for new indications such as mass drug administrations for the treatment of scabies or in malaria vector control. As its pharmacokinetics are still poorly understood, we aimed to characterize the population pharmacokinetics of ivermectin in plasma and dried blood spots (DBS), a sampling method better suited to field trials, with special focus on the influence of body composition and enterohepatic circulation.

Methods

We performed a clinical trial in 12 healthy volunteers who each received a single oral dose of 12 mg ivermectin, and collected peripheral venous and capillary DBS samples. We determined ivermectin concentrations in plasma and DBS by liquid chromatography tandem mass spectrometr

SUBMITTER: Duthaler U 

PROVIDER: S-EPMC6379217 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature