A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients.

ABSTRACT:

Aims

The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.

Methods

Data on tacrolimus exposure were collected for the first 3 months following renal transplantation. A population pharmacokinetic analysis was conducted using nonlinear mixed-effects modelling. Demographic, clinical and genetic parameters were evaluated as covariates.

Results

A total of 4527 tacrolimus blood samples collected from 337 kidney transplant recipients were available. Data were best described using a two-compartment model. The mean absorption rate was 3.6 h^-1 , clearance was 23.0 l h^-1 (39% interindividual variability, IIV),

SUBMITTER: Andrews LM 

PROVIDER: S-EPMC6379219 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature