The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients.

ABSTRACT:

Aims

Tacrolimus has been associated with notable extrarenal adverse effects (AEs), which are unpredictable and impact patient morbidity. The association between model-predicted tacrolimus exposure metrics and standardized extrarenal AEs in stable renal transplant recipients was investigated and a limited sampling strategy (LSS) was developed to predict steady-state tacrolimus area under the curve over a 12-h dosing period (AUC_ss,0-12h ).

Methods

All recipients receiving tacrolimus and mycophenolic acid ≥6 months completed a 12-h cross-sectional observational pharmacokinetic-pharmacodynamic study. Patients were evaluated for the presence of individual and composite gastrointestinal, neurological, and aesthetic AEs during the study visit. The associations between AE

SUBMITTER: Campagne O 

PROVIDER: S-EPMC6379234 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature