Mouse Skull Mean Shape and Shape Robustness Rely on Different Genetic Architectures and Different Loci.

ABSTRACT: The genetic architecture of skull shape has been extensively studied in mice and the results suggest a highly polygenic and additive basis. In contrast few studies have explored the genetic basis of the skull variability. Canalization and developmental stability are the two components of phenotypic robustness. They have been proposed to be emergent properties of the genetic networks underlying the development of the trait itself, but this hypothesis has been rarely tested empirically. Here we use outbred mice to investigate the genetic architecture of canalization of the skull shape by implementing a genome-wide marginal epistatic test on 3D geometric morphometric data. The same data set had been used previously to explore the genetic architecture of the skull mean shape and its developmen

SUBMITTER: Varon-Gonzalez C 

PROVIDER: S-EPMC6379267 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature