Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration.

ABSTRACT: Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. Cholesterol is a component of membrane rafts and the integrity of these structures depends on the concentrations present of this compound. Here we explored the effect of cholesterol depletion in both developing neurons and regenerating axons. First, we show that cholesterol depletion in vitro in developing neurons from the central and peripheral nervous systems increases the size of growth cones, the density of filopodium-like structures and the number of neurite branching points. Next, we demonstrate that cholesterol depletion enhances axonal regeneration

SUBMITTER: Rosello-Busquets C 

PROVIDER: S-EPMC6379282 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature