Characterization of Endothelial and Smooth Muscle Cells From Different Canine Vessels.

ABSTRACT: Vasculature performs a critical function in tissue homeostasis, supply of oxygen and nutrients, and the removal of metabolic waste products. Vascular problems are implicated in a large variety of pathologies and accurate in vitro models resembling native vasculature are of great importance. Unfortunately, existing in vitro models do not sufficiently reflect their in vivo counterpart. The complexity of vasculature requires the examination of multiple cell types including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), as well as vessel location in the body from which they originate. The use of canine blood vessels provides a way to study vasculature with similar vessel size and physiology compared to human vasculature. We report an isolation procedure

SUBMITTER: Oosterhoff LA 

PROVIDER: S-EPMC6379353 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature