Aurora A controls CD8⁺ T cell cytotoxic activity and antiviral response.

ABSTRACT: Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4⁺ T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8⁺ T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8⁺ T cells. This finding was similarly proven for both mice and human CD8⁺ CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activatio

SUBMITTER: Bustos-Moran E 

PROVIDER: S-EPMC6379542 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature