Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages.

ABSTRACT: The liver X receptors α and β (LXRα and LXRβ) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. In addition to their roles in lipid metabolism, LXRs participate in the transcriptional regulation of macrophage activation and are considered potent regulators of inflammation. LXRs are highly similar, and despite notable exceptions, most of their reported functions are substantially overlapping. However, their individual genomic distribution and transcriptional capacities have not been characterized. Here, we report a macrophage cellular model expressing equivalent levels of tagged LXRs. Analysis of data from chromatin immunoprecipitation coupled with deep sequencing revealed that LXRα and LXRβ

SUBMITTER: Ramon-Vazquez A 

PROVIDER: S-EPMC6379585 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature