Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial.

ABSTRACT:

Background

It is uncertain whether vitamin D can reduce respiratory infection.

Objective

To determine whether vitamin D supplementation reduces influenza and other upper viral respiratory tract infections.

Methods

A total of 1300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14 000 U weekly) or placebo for 8 months in Vietnam. The primary outcome was reverse transcriptase (RT)-PCR-confirmed influenza infection, and the coprimary outcome was multiplex PCR-confirmed non-influenza respiratory viruses. Participants, caregivers, and those assessing outcomes were blinded to group assignment.

Results

A total of 650 children and adolescents were randomly assigned to vitamin D and 650 to placebo. The mean baseline seru

SUBMITTER: Loeb M 

PROVIDER: S-EPMC6379634 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature