Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan.

ABSTRACT:

Background

The large consumption of neuraminidase inhibitors (NAIs) for the treatment of influenza virus infections places Japan at risk of becoming the epicenter of the global spread of NAI-resistant viruses.

Objective

To clarify NA amino acid mutations of epidemic influenza viruses in Japan and their related NAI resistance.

Methods

A total of 1791 samples, including 396 A/H1N1pdm09, 1117 A/H3N2, and 278 B isolates, were collected to determine of their 50% inhibitory concentration (IC₅₀ ) values by NAIs (oseltamivir, zanamivir, peramivir, and laninamivir) during the Japanese seasons from 2011-2012 to 2016-2017. Then, 380 samples including 49 A/H1N1pdm09, 251 A/H3N2, and 80 B isolates were sequenced for the entire NA genes.

Results

Neuraminidase inhi

SUBMITTER: Chong Y 

PROVIDER: S-EPMC6379637 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature