Ontology highlight
ABSTRACT:
SUBMITTER: Bertolet G
PROVIDER: S-EPMC6379685 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Life science alliance 20190218 1
The prevailing model of microRNA function is that the "seed region" (nt 2-8) is sufficient to mediate target recognition and repression. However, numerous recent studies have challenged this model, either by demonstrating extensive 3' pairing between physically defined miRNA-mRNA pairs or by showing in <i>Caenorhabditis elegans</i> that disrupted 3' pairing can result in impaired function in vivo. To test the importance of miRNA 3' pairing in a mammalian system in vivo, we engineered a mutant mu ...[more]