Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer.

ABSTRACT:

Background

Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer (CRC) onset that could improve clinical strategies.

Aim

To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.

Methods

A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumor-node-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems (Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131H/R and FcγRIIIa-158V/F was carr

SUBMITTER: Berghella AM 

PROVIDER: S-EPMC6379753 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature