Neonatal genistein exposure disrupts ovarian and uterine development in the mouse by inhibiting cellular proliferation.

ABSTRACT: Soy-based formula contains high concentrations of the isoflavone genistein. Genistein possesses estrogenic and tyrosine kinase inhibitory activity and interferes with cellular proliferation and development. To date, the acute and chronic effects of genistein on ovarian and uterine development have not been fully elucidated. In this study, mice at postnatal day 1 were subcutaneously injected with 100 mg/kg genistein for 10 consecutive days, and then their ovaries and uteri were collected on days 10, 21, and 90. Histological evaluation was performed after hematoxylin and eosin staining. The proliferating activity was indicated by the proliferating indicator protein Ki67. Results showed that the subcutaneous injection of genistein to neonatal mice induced the formation of multi-oocyte follicl

SUBMITTER: Wu G 

PROVIDER: S-EPMC6379766 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature