Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2.

ABSTRACT:

Introduction

Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been studied in the context of thrombosis, and may be a unique contributor to thrombotic disease. Here we utilize mice lacking SLC44A2 (Slc44a2^-/-) to evaluate a possible role of SLC44A2 in hemostasis.

Methods

Slc44a2^-/- mice were evaluated in key aspects of normal hemostasis including a challenge of vascular damage by applying laser induced injury to the cremaster muscle arteriole.

Results

Slc44a2^-/- mice had comparable levels of thrombin generation and gene expression of coagulation related genes,

SUBMITTER: Tilburg J 

PROVIDER: S-EPMC6379912 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature