Impact of two oral doses of 100,000 IU of vitamin D₃ in preschoolers with viral-induced asthma: a pilot randomised controlled trial.

ABSTRACT:

Background

New evidence supports the use of supplemental vitamin D in the prevention of exacerbation of asthma; however, the optimal posology to sufficiently raise serum levels while maximising adherence is unclear. The objective was to ascertain the efficacy of high-dose vitamin D₃ in increasing serum vitamin D in preschoolers with asthma and provide preliminary data on safety and efficacy outcomes.

Methods

We conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1-5 years with viral-induced asthma. Participants were allocated to receive two oral doses of 100,000 IU vitamin D₃ (intervention) or identical placebo (control) 3.5 months apart, once in the fall and once in the winter. Serum 25-hydroxyvitamin D (25OH

SUBMITTER: Ducharme FM 

PROVIDER: S-EPMC6379931 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature