A unique insight into the MiRNA profile during genital chlamydial infection.

ABSTRACT:

Background

Genital C. trachomatis infection may cause pelvic inflammatory disease (PID) that can lead to tubal factor infertility (TFI). Understanding the pathogenesis of chlamydial complications including the pathophysiological processes within the female host genital tract is important in preventing adverse pathology. MicroRNAs regulate several pathophysiological processes of infectious and non-infectious etiologies. In this study, we tested the hypothesis that the miRNA profile of single and repeat genital chlamydial infections will be different and that these differences will be time dependent. Thus, we analyzed and compared differentially expressed mice genital tract miRNAs after single and repeat chlamydia infections using a C. muridarum mouse model. Mice were sacrificed and

SUBMITTER: Benyeogor I 

PROVIDER: S-EPMC6379932 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature