Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries. Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been hypothesized to be a possible etiology. However, establishing a causal relationship between microbial inflammation and PCa requires a comprehensive analysis of the prostate microbiome. The aim of this study was to characterize the microbiome in prostate tissue of PCa patients and investigate its association with tumour clinical characteristics as well as host expression profiles.

Results

The metagenome and metatranscriptome of tumour and the adjacent benign tissues were assessed in 65 Chinese radical prostatectomy specimens. Escherichia, Propionibacterium, Acinetoba

SUBMITTER: Feng Y 

PROVIDER: S-EPMC6379980 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature