Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression.

ABSTRACT:

Background

Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

Methods

Here we generated circRNA microarray data from three BC tissues and paired non-cancerous matched tissues, and detected circular RNA-cTFRC up-regulated and correlated with tumor grade and poor survival rate of BC patients. We subsequently performed functional analyses in cell lines and an animal model to support clinical findings. Mechanistically, we demonstrated that cTFRC could directly bind to miR-107 and relieve suppression for target TFRC expression.

Results

We detected circular RNA-cTFRC up-regulated and correlated with tumor grade and poor

SUBMITTER: Su H 

PROVIDER: S-EPMC6379985 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature