A functional variant alters binding of activating protein 1 regulating expression of FGF7 gene associated with chronic obstructive pulmonary disease.

ABSTRACT:

Background

Genome-wide association studies (GWASs) of a large cohort of subjects with chronic obstructive pulmonary disease (COPD) have successfully identified multiple risk genes, including fibroblast growth factor 7 (FGF7). However, the underlying molecular mechanism influencing function of FGF7 and risk of COPD remains further study.

Methods

In this study, we replicated the genetic association of variants near the FGF7 gene in 258 Chinese Han patients with COPD and 311 healthy controls. Additionally, we functionally evaluated a candidate causal variant upstream of the FGF7 gene.

Results

The most significant association was observed at rs12905203 (P = 5.9 × 10^- 3, odd ratio, OR = 1.516) that explains associations of previously reported variants at the FGF

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6380023 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature