Dietary iron interacts with genetic background to influence glucose homeostasis.

ABSTRACT:

Background

Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between iron metabolism and metabolic health is well established, the extent to which dietary iron contributes to metabolic disease risk is unexplored. Further, it is unknown how dietary iron interacts with genetic background to modify metabolic disease risk.

Methods

LG/J and SM/J inbred mouse strains were used to investigate the relationship between genetic background and metabolic function during an 8-week high iron diet. Glucose tolerance and adiposity were assessed, colorimetric assays determined levels of circulating metabolic markers, and hepatic iron content w

SUBMITTER: Miranda MA 

PROVIDER: S-EPMC6380031 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature