Patterns of body mass index milestones in early life and cardiometabolic risk in early adolescence.

ABSTRACT:

Background

Few studies have examined the independent and combined relationships of body mass index (BMI) peak and rebound with adiposity, insulin resistance and metabolic risk later in life. We used data from Project Viva, a well-characterized birth cohort from Boston with repeated measures of BMI, to help fill this gap.

Methods

Among 1681 children with BMI data from birth to mid childhood, we fitted individual BMI trajectories using mixed-effects models with natural cubic splines and estimated age, and magnitude of BMI, at peak (in infancy) and rebound (in early childhood). We obtained cardiometabolic measures of the children in early adolescence (median 12.9 years) and analysed their associations with the BMI parameters.

Results

After adjusting for potential confoun

SUBMITTER: Aris IM 

PROVIDER: S-EPMC6380298 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature