The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles.

ABSTRACT: Ribosome synthesis is an essential cellular process, and perturbation of human ribosome production is linked to cancer and genetic diseases termed ribosomopathies. During their assembly, pre-ribosomal particles undergo numerous structural rearrangements, which establish the architecture present in mature complexes and serve as key checkpoints, ensuring the fidelity of ribosome biogenesis. RNA helicases are essential mediators of such remodelling events and here, we demonstrate that the DEAH-box RNA helicase DHX37 is required for maturation of the small ribosomal subunit in human cells. Our data reveal that the presence of DHX37 in early pre-ribosomal particles is monitored by a quality control pathway and that failure to recruit DHX37 leads to pre-rRNA degradation. Using an in vivo crossli

SUBMITTER: Choudhury P 

PROVIDER: S-EPMC6380342 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature