Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells.

ABSTRACT: Circular RNA (circRNA) is a novel RNA molecule that has become a research focus recently. Although some research indicated that the circRNAs in different subcellular compartments could execute different regulatory functions, a panoramic analysis of the subcellular distribution and the transport mechanism of circRNA is still required. In this study, we comprehensively analyzed the subcellular distribution/characteristics and the transport mechanism, through systemically investigating the circRNA profiles among the subcellular fractions of HepG2 cell (nucleus, cytoplasm, mitochondria, ribosome, cytosol and exosome). CircRNAs were widely distributed among the subcellular fractions except in the mitochondria, with differences in the subcellular distribution/characteristics in terms of classifi

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6380345 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature