Anti-HIV IgM protects against mucosal SHIV transmission.

ABSTRACT:

Objective

Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory IgM. We sought to investigate for the first time the role of IgM in preventing AIDS virus acquisition in vivo.

Design

Recombinant polymeric monoclonal IgM was generated from the neutralizing monoclonal IgG1 antibody 33C6-IgG1, tested in vitro, and given by passive intrarectal immunization to rhesus macaques 30 min before intrarectal challenge with simian-human immunodeficiency virus (SHIV) that carries an HIV-1 envelope gene.

Results

In vitro, 33C6-IgM captured virions more efficiently and neutralized the challenge SHIV wi

SUBMITTER: Gong S 

PROVIDER: S-EPMC6380498 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature