Associations between use of macrolide antibiotics during pregnancy and adverse child outcomes: A systematic review and meta-analysis.

ABSTRACT:

Background

Evidence on adverse effects of maternal macrolide use during pregnancy is inconsistent. We conducted a systematic review and meta-analysis to investigate the association between macrolide use during pregnancy and adverse fetal and child outcomes.

Methods and findings

We included observational studies and randomised controlled trials (RCTs) that recorded macrolide use during pregnancy and child outcomes. We prioritized comparisons of macrolides with alternative antibiotics (mainly penicillins or cephalosporins) for comparability of indication and effect. Random effects meta-analysis was used to derive pooled odds ratios (OR) for each outcome. Subgroup analyses were performed according to specific types (generic forms) of macrolide. Of 11,186 citations identified, 1

SUBMITTER: Fan H 

PROVIDER: S-EPMC6380581 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature