Training set optimization of genomic prediction by means of EthAcc.

ABSTRACT: Genomic prediction is a useful tool for plant and animal breeding programs and is starting to be used to predict human diseases as well. A shortcoming that slows down the genomic selection deployment is that the accuracy of the prediction is not known a priori. We propose EthAcc (Estimated THeoretical ACCuracy) as a method for estimating the accuracy given a training set that is genotyped and phenotyped. EthAcc is based on a causal quantitative trait loci model estimated by a genome-wide association study. This estimated causal model is crucial; therefore, we compared different methods to find the one yielding the best EthAcc. The multilocus mixed model was found to perform the best. We compared EthAcc to accuracy estimators that can be derived via a mixed marker model. We showed that EthA

SUBMITTER: Mangin B 

PROVIDER: S-EPMC6380617 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature