A multidisciplinary perspective on the subcutaneous administration of trastuzumab in HER2-positive breast cancer.

ABSTRACT: Trastuzumab is the standard treatment in Canada for patients with breast cancer positive for her2 (human epidermal growth factor receptor 2), dramatically improving outcomes in that patient group. However, its current intravenous (IV) administration is associated with long infusion times that place a significant burden on health care resources and patient quality of life. In an effort to provide a faster and easier administration method, a subcutaneous (sc) formulation of trastuzumab has been developed. Data from comparative trials demonstrate that the two formulations are comparable with respect to pharmacokinetics and efficacy. They also have similar safety profiles, with the exception of mild local and administration reactions with the sc formulation. Furthermore, the sc formulation is

SUBMITTER: Dent S 

PROVIDER: S-EPMC6380645 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature