Pulse sequence considerations for quantification of pyruvate-to-lactate conversion k_PL in hyperpolarized ¹³ C imaging.

ABSTRACT: Hyperpolarized ¹³ C MRI takes advantage of the unprecedented 50 000-fold signal-to-noise ratio enhancement to interrogate cancer metabolism in patients and animals. It can measure the pyruvate-to-lactate conversion rate, k_PL , a metabolic biomarker of cancer aggressiveness and progression. Therefore, it is crucial to evaluate k_PL reliably. In this study, three sequence components and parameters that modulate k_PL estimation were identified and investigated in model simulations and through in vivo animal studies using several specifically designed pulse sequences. These factors included a magnetization spoiling effect due to RF pulses, a crusher gradient-induced flow suppression, and intrinsic image weightings due to relaxation. Simulation showed t

SUBMITTER: Chen HY 

PROVIDER: S-EPMC6380928 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature