Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.

ABSTRACT: Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose organic bases were previously completely unknown. Microglia, immune cells in the brain, are regarded to play crucial roles in brain inflammation by releasing inflammatory mediators and are suggested to contribute to various psychiatric disorders such as depression and schizophrenia. Recently, activated microglia have been suggested to be one of the possible contributing cells to suicide and suicidal behaviors via various mechanisms especially including the tryptophan-kynurenine pathway. Animal model research focusing on psychiatric disord

SUBMITTER: Suzuki H 

PROVIDER: S-EPMC6381042 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature