Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism.

ABSTRACT: Paramyxoviruses, specifically, the childhood pathogen human parainfluenza virus type 3, are internalized into host cells following fusion between the viral and target cell membranes. The receptor binding protein, hemagglutinin (HA)-neuraminidase (HN), and the fusion protein (F) facilitate viral fusion and entry into the cell through a coordinated process involving HN activation by receptor binding, which triggers conformational changes in the F protein to activate it to reach its fusion-competent state. Interfering with this process through premature activation of the F protein has been shown to be an effective antiviral strategy in vitro. Conformational changes in the F protein leading to adoption of the postfusion form of the protein-prior to receptor engagement of HN at the host

SUBMITTER: Bottom-Tanzer SF 

PROVIDER: S-EPMC6381285 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature