Adjunctive simvastatin for treatment-resistant depression: study protocol of a 12-week randomised controlled trial.

ABSTRACT:

Background

A third of patients diagnosed with major depressive disorder (MDD) experience treatment-resistant depression (TRD). Relatively few pharmacological agents have established efficacy for TRD. Therefore, the evaluation of novel treatments for TRD is a pressing priority. Statins are pleiotropic agents and preclinical studies as well as preliminary clinical trials have suggested that these drugs may have antidepressant properties.AimsTo report on a protocol for a 12-week, randomised, double-blind, placebo-controlled trial of add-on treatment with simvastatin for patients meeting DSM-5 criteria for MDD who have failed to respond to at least two adequate trials with approved antidepressants. The trial has been registered with Clinicaltrials.gov in (ClinicalTrials.gov identifier:

SUBMITTER: Husain MI 

PROVIDER: S-EPMC6381416 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature