Genome plasticity favours double chromosomal Tn4401b-bla_KPC-2 transposon insertion in the Pseudomonas aeruginosa ST235 clone.

ABSTRACT:

Background

Pseudomonas aeruginosa Sequence Type 235 is a clone that possesses an extraordinary ability to acquire mobile genetic elements and has been associated with the spread of resistance genes, including genes that encode for carbapenemases. Here, we aim to characterize the genetic platforms involved in resistance dissemination in bla_KPC-2-positive P. aeruginosa ST235 in Colombia.

Results

In a prospective surveillance study of infections in adult patients attended in five ICUs in five distant cities in Colombia, 58 isolates of P. aeruginosa were recovered, of which, 27 (46.6%) were resistant to carbapenems. The molecular analysis showed that 6 (22.2%) and 4 (14.8%) isolates harboured the bla_VIM and bla_KPC-2 genes, respectively. The four

SUBMITTER: Abril D 

PROVIDER: S-EPMC6381643 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature