Tissue specificity of in vitro drug sensitivity.

ABSTRACT:

Objectives

We sought to investigate the tissue specificity of drug sensitivities in large-scale pharmacological studies and compare these associations to those found in drug clinical indications.

Materials and methods

We leveraged the curated cell line response data from PharmacoGx and applied an enrichment algorithm on drug sensitivity values' area under the drug dose-response curves (AUCs) with and without adjustment for general level of drug sensitivity.

Results

We observed tissue specificity in 63% of tested drugs, with 8% of total interactions deemed significant (false discovery rate <0.05). By restricting the drug-tissue interactions to those with AUC > 0.2, we found that in 52% of interactions, the tissue was predictive of drug sensitivity (concordance index > 

SUBMITTER: Yao F 

PROVIDER: S-EPMC6381764 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature