Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies.

ABSTRACT: Thyroid hormones take major part in normal growth, development and metabolism. Over a century of research has supported a relationship between thyroid hormones and the pathophysiology of various cancer types. In vitro studies as well as research in animal models demonstrated an effect of the thyroid hormones T3 and T4 on cancer proliferation, apoptosis, invasiveness and angiogenesis. Thyroid hormones mediate their effects on the cancer cell through several non-genomic pathways including activation of the plasma membrane receptor integrin αvβ3. Furthermore, cancer development and progression are affected by dysregulation of local bioavailability of thyroid hormones. Case-control and population-based studies provide conflicting results regarding the association between thyroid hormone

SUBMITTER: Krashin E 

PROVIDER: S-EPMC6381772 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature