Lack of Longitudinal Association Between Thiazolidinediones and Incidence and Progression of Diabetic Eye Disease: The ACCORD Eye Study.

ABSTRACT:

Purpose

To report the longitudinal association between use of thiazolidinediones (TZDs), visual acuity (VA) change, and diabetic eye disease incidence and progression.

Design

Cohort study ancillary to a randomized clinical trial.

Methods

We analyzed baseline and 4-year follow-up data of 2856 ACCORD trial participants with no history of proliferative diabetic retinopathy. Based on stereoscopic fundus photographs, we evaluated diabetic macular edema (DME) progression and DR progression. We also evaluated 10- and 15-letter change on the ETDRS visual acuity chart. Main outcome measures were incidence or progression of DME or DR and change in visual acuity.

Results

TZD use was not associated with DME incidence in either the analysis of any use (adjusted odds ratio [

SUBMITTER: Gower EW 

PROVIDER: S-EPMC6381823 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature