Usefulness of Non-Invasive Fetal RHD Genotyping towards Immunoprophylaxis Optimization.

ABSTRACT: Introduction: Since anti-D immunoprophylaxis given to D-negative pregnant women is a blood product, blood donations have an impact on the availability of prophylactic doses. The Pan American Health Organization reported, in June 2017, that less than half of blood donors are volunteers in Latin America and the Caribbean. In these countries, guidelines for use of anti-D prophylaxis are still controversial. The aim of this study was to demonstrate the convenience of a simple and cost-effectivene non-invasive prenatal diagnostic assay for anti-D prophylaxis optimization in multiethnic populations. Methods: Cell-free fetal DNA from plasma samples of D-negative pregnant women were analyzed by real-time PCR for simultaneous amplification of sequences of exons 5 and 10 of the RHD<

SUBMITTER: Blanco S 

PROVIDER: S-EPMC6381923 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature