Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial.

ABSTRACT:

Purpose

27-hydroxycholesterol (27HC), an endogenous selective estrogen receptor modulator (SERM), drives the growth of estrogen receptor-positive (ER+) breast cancer. 1,25-dihydroxyvitamin D (1,25(OH)₂D), the active metabolite of vitamin D, is known to inhibit expression of CYP27B1, which is very similar in structure and function to CYP27A1, the synthesizing enzyme of 27HC. Therefore, we hypothesized that 1,25(OH)₂D may also inhibit expression of CYP27A1, thereby reducing 27HC concentrations in the blood and tissues that express CYP27A1, including breast cancer tissue.

Methods

27HC, 25-hydroxyvitamin D (25OHD), and 1,25(OH)₂D were measured in sera from 29 breast cancer patients before and after supplementation with low-dose (400 IU/day) or hi

SUBMITTER: Going CC 

PROVIDER: S-EPMC6381934 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature