Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease.

ABSTRACT:

Objective

To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD).

Methods

We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [¹⁸F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [¹⁸F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed to examine associat

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC6382060 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature