Safety and Efficacy of OnabotulinumtoxinA for Treatment of Crow's Feet Lines in Chinese Subjects.

ABSTRACT:

Background

This study evaluated the safety and efficacy of onabotulinumtoxinA for the treatment of crow's feet lines (CFL) in Chinese subjects.

Methods

This 5-month, double-blind, randomized, parallel-group, placebo-controlled phase 3 study was conducted in China. Subjects with moderate-to-severe CFL at maximum smile received a single treatment of onabotulinumtoxinA 24 U (total; n = 316) or placebo (n = 101) on day 1. The primary efficacy measure was the proportion of investigator-assessed responders (achieved CFL severity of none or mild at maximum smile using the Facial Wrinkle Scale with Asian Photonumeric Guide at day 30). Additional endpoints included other response definitions (achieving at least 1-grade improvement at maximum smile and at rest using the Facial Wrinkle

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6382241 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature