Most sleep does not serve a vital function: Evidence from Drosophila melanogaster.

ABSTRACT: Sleep appears to be a universally conserved phenomenon among the animal kingdom, but whether this notable evolutionary conservation underlies a basic vital function is still an open question. Using a machine learning-based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a lifelong chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type D. melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biolog

SUBMITTER: Geissmann Q 

PROVIDER: S-EPMC6382397 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature