The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.

ABSTRACT: Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective host defense toward invasive intestinal bacteria can result in chronic inflammation. We have shown that macrophages differentiated in the presence of the bacterial metabolite butyrate display enhanced antimicrobial activity. Butyrate-induced antimicrobial activity was associated with a shift in macrophage metabolism, a reduction in mTOR kinase activity, increased LC3-associated host defense and anti-microbial peptide production in the absence of an increased inflammatory cytokine response. Butyrate drove this monocyte to macrophage differentiation program through histone deacetylase 3 (HDAC3) inhibition. Administration of butyrate induc

SUBMITTER: Schulthess J 

PROVIDER: S-EPMC6382411 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature