MAPT rs242557 variant is associated with hippocampus tau uptake on ¹⁸F-AV-1451 PET in non-demented elders.

ABSTRACT: The microtubule-associated protein tau gene (MAPT) rs242557 variant is associated with multiple tauopathies and dementia. This study investigated whether it was correlated with brain tau-PET uptake in non-demented elders. Ninety non-demented elders were identified from the Alzheimer's Disease Neuroimaging Initiative cohort. We compared standardized uptake value ratios (SUVRs) of tau-PET tracer ¹⁸F-AV-1451 between rs242557 variant carriers and non-carriers in 25 regions of interest (ROIs). The minor allele A was associated with increased hippocampus ¹⁸F-AV-1451 uptake in non-demented elders (left: β = 0.111, Bonferroni corrected p = 0.035; right: β = 0.103, Bonferroni corrected p = 0.031). Aβ-positive participants (left: β = 0.206, Bonferroni corrected p = 0.029

SUBMITTER: Shen XN 

PROVIDER: S-EPMC6382414 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature