Predicting chromosome 1p/19q codeletion by RNA expression profile: a comparison of current prediction models.

ABSTRACT:

Background

Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might influence the clinical management for doctors. Here, we attempted to explore an RNA sequencing computational method to detect 1p/19q status.

Methods

We included 692 samples with 1p/19q status information from TCGA cohort as training set and 222 samples with 1p/19q status information from REMBRANDT cohort as validation set. We reviewed and compared five tools: TSPairs, GSVA, PAM, Caret, smoother, with respect to their accuracy, sensitivity and specificity.

Res

SUBMITTER: Wang ZL 

PROVIDER: S-EPMC6382420 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature