Lack of association of the IL-1RN and IL-10 polymorphisms with risk of psoriasis: A meta-analysis.

ABSTRACT:

Background

The present study carried out a meta-analysis to investigate whether the interleukin-1 receptor antagonist (IL-1RN) VNTR polymorphism and three IL-10 single-nucleotide polymorphisms (SNPs) rs1800896, rs3021097, and rs1800872 are associated with psoriasis risk.

Methods

Wanfang, China National Knowledge Infrastructure, Medline, and PubMed databases were searched for potential studies published until 2 November 2017. Forest plots were generated.

Results

Thirteen case-control studies were included in the review. The results of meta-analyses revealed no association of the IL-1RN*2 allele with psoriasis in the overall populations (odds ratio [OR] = 1.16, 95% confidence intervals [CI]: 0.89-1.50, p = 0.279), Asians (OR = 1.27, 95% CI: 0.73-2.23, p = 0.403), and Ca

SUBMITTER: Qiao J 

PROVIDER: S-EPMC6382441 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature